rac-(6S)-6-Hydroxy-6-{2-[2-(propan-2-ylidene)hydrazinylidene]propyl}indolo[2,1-b]quinazolin-12(6H)-one
نویسندگان
چکیده
The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, mol-ecules form centrosymmetric π-overlapping dimers [inter-planar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O-H⋯N hydrogen bonds. C-H⋯O inter-actions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small dihedral angle of 6.3 (4)° between the plane of the quinazoline system and the plane of the benzene ring of the indole moiety. The C=N-N=C atoms of the azine group is oriented almost perpendicular [84.1 (2)°] to the mean plane of the quinazoline system.
منابع مشابه
7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione
There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(6)Cl(2)N(2)O(2). The conjugated four-ring system is essentially planar in each mol-ecule [maximum deviation = 0.089 (2) Å]. In the crystal, weak inter-molecular C-H⋯Cl, C-H⋯O and C-H⋯·N inter-actions help to stabilize the packing.
متن کامل3-Chloro-6-[2-(propan-2-ylidene)hydrazinyl]pyridazine
In the title compound, C(7)H(9)ClN(4), the 3-chloro-6-hydrazinylpyridazine unit is planar (r.m.s. deviation = 0.0219 Å) and is oriented at a dihedral angle 4.66 (27)° with respect to the propan-2-yl-idene group. In the crystal, the mol-ecules are linked into non-planar dimers due to a crystallographic twofold rotation via N-H⋯N hydrogen bonds with R(2) (2)(8) graph-set ring motifs.
متن کاملSynthesis with nitriles: synthesis of some new mercaptopyridazine, mercaptopyridazino[1,6-a]quinazoline and thiophene derivatives.
2-(1-(4-Bromophenyl)-2-thiocyanatoethylidene)malononitrile (3) undergoes azo coupling with diazotized aromatic amines to afford arylhydrazone derivatives, which are readily cyclized to afford the corresponding 3(2H)-pyridazinimine derivatives upon reflux in aqueous NaOH. Under similar condition an o-cyanoarylhydrazone derivative was cyclized into 6H-pyridazino[1,6-a]quinazolin-6-imine, which in...
متن کامل11-(2-Oxopyrrolidin-1-ylmethyl)-1,2,3,4,5,6,11,11a-octahydropyrido[2,1-b]quinazolin-6-one dihydrate
In the crystal structure of the title compound, C(17)H(21)N(3)O(2)·2H(2)O, water mol-ecules are mutually O-H⋯O hydrogen bonded and form infinite chains propagating along the b axis. Neighboring chains are linked by the quinazoline mol-ecules by means of O-H⋯O=C hydrogen bonds, forming a two-dimensional network.
متن کاملrac-4-Chloro-2-[({2-[(3-chloro-6-hydroxy-2,4-dimethylbenzyl)(methyl)amino]propyl}(methyl)amino)methyl]-3,5-dimethylphenol
The title compound, C(23)H(32)Cl(2)N(2)O(2), a potential chiral ligand for coordination chemistry, was prepared by a two-step reaction. The mol-ecule is located on a crystallographic centre of inversion. As a result, the methyl group bonded to the methyl-ene group is disordered over two equally occupied positions, sharing the same site as the H atom of the chiral C atom. As a further consequenc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 67 شماره
صفحات -
تاریخ انتشار 2011